B-Cell Lymphoma

Information and resources on B Cell lymphoma including follicular lymphoma, burkitt's lymphoma as well as symptoms and treatment.

T cell-dependent B cell activation, showing a TH2-cell (left), B cell (right), and several interaction molecules wikipedia

T cell-dependent B cell activation, showing a (left), B cell (right), and several interaction molecules wikipedia

Immune system

New cancer treatment beats chemotherapy without the toxic side effects By Brian Dodson June 2013 Schematic of how B-cells work within the immune system response (Photo: National Institute.

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IHC for ALL:  Precursor B = Tdt, HLA-DR, 19, 10 (in the t(1;19) and +/- 20.  Burkitt = HLA-DR, 19, 20, sIg, and +/- 10 but TdT negative. Precursor t = TdT, CD7 but DR negative.

IHC for ALL: Precursor B = Tdt, HLA-DR, 19, 10 (in the t(1;19) and +/- 20. Burkitt = HLA-DR, 19, 20, sIg, and +/- 10 but TdT negative. Precursor t = TdT, CD7 but DR negative.

Figure 1: Schematic diagram to explain mechanisms of clonal selection of B cell, and how secondary immune response is stronger, quicker and more specific in comparison with the primary one.

Figure Schematic diagram to explain mechanisms of clonal selection of B cell, and how secondary immune response is stronger, quicker and more specific in comparison with the primary one.

Monitoring Memory B cell Number to keep Efficacy and Increase Safety Grant Ideas for Free Monthly In this issueI have predicted that this will be the year of the B cell as I expect ocrelizumab to get a licence for the treatment of relapsing MS or perhaps even active (relapsing & progressive) MS. We have got the year off to a flying B cell start with our recent paper which shifts the focus from the T cell onto the B cell and notably the memory B cell subsets. We have made an argument that…

Monitoring Memory B cell Number to keep Efficacy and Increase Safety

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Childhood MS shows us that Memory B cells are Important in MS     Schwarz A Balint B Korporal-Kuhnke M Jarius S von Engelhardt K Fürwentsches A Bussmann C Ebinger F Wildemann B Haas J.B-cell populations discriminate between pediatric- and adult-onsetmultiple sclerosis.Neurol Neuroimmunol Neuroinflamm. 2016;4(1):e309  OBJECTIVE:  METHODS:  RESULTS:  CONCLUSIONS:  This provides further evidence for a role of B cell memory in MS. The authors are not looking for anything other than B cells and…

Childhood MS shows us that Memory B cells are Important in MS

Antibody-independent functions of B cells: a focus on cytokines : Cytokine production by B cells is important for multiple aspects of immunity. B cell-derived cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and activation of secondary lymphoid organs, as well as for the development of tertiary lymphoid tissues at ectopic sites. Other B cell-derived cytokines, such as interleukin-6 (IL-6), interferon-γ and tumour necrosis factor, influence the development of…

Antibody-independent functions of B cells: a focus on cytokines : Cytokine production by B cells is important for multiple aspects of immunity. B cell-derived cytokines, including lymphotoxin, are essential for the ontogenesis, homeostasis and activation of secondary lymphoid organs, as well as for the development of tertiary lymphoid tissues at ectopic sites. Other B cell-derived cytokines, such as interleukin-6 (IL-6), interferon-γ and tumour necrosis factor, influence the development of…

A T cell to Help the CNS B cell?   The problem in MS could be the B cell follicles sometimes found in CNS. These were described years earlier in rheumatoid arthritis so it is intersting that recently it has been reported that there is a T cell subset that helps the B cells to do their thang.If you look in a B cell follicle of a lymph gland you find CD4 T cells. These have got the name of Follicular B helper T cells (also known as just follicular helper T cells or TFH) are antigen-experienced…

A T cell to Help the CNS B cell? The problem in MS could be the B cell follicles sometimes found in CNS. These were described years earlier in rheumatoid arthritis so it is intersting that recently it has been reported that there is a T cell subset that helps the B cells to do their thang.If you look in a B cell follicle of a lymph gland you find CD4 T cells. These have got the name of Follicular B helper T cells (also known as just follicular helper T cells or TFH) are antigen-experienced…

Original antigenic sin.svg

Original antigenic sin - Wikipedia, the free encyclopedia

Lymph containing lymphocytes, antigen, and soluble mediators drains from surrounding tissues and enters the lymph nodes via afferent lymphatic vessels. The lymph node consists of a cortex and a medulla. The outermost area of the cortex has B cells organized into lymphoid follicles, and its deep, or paracortical, area consists mainly of T cells and dendritic cells. After B cells encounter antigens for which they have receptors, along with the appropriate T cells, central areas of marked B…

Lymph containing lymphocytes, antigen, and soluble mediators drains from surrounding tissues and enters the lymph nodes via afferent lymphatic vessels

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