Here's the perfect 10 day road trip itinerary from Milan to Rome, a popular tourist route. It's only a 6 hour drive. But this well-traveled Italian road trip route is dense with enchanting medieval villages, ornate palazzos, Roman ruins, and sublime treasures of the Renaissance. This Italy itinerary takes you to Italy's must see sites, must visit towns, historic landmarks, and world class museums. I also offer day trip options and tips for extending your vacation in bella Italy. #italy #rome